design, synthesis, antimalarial evaluation and computational studies of some chalcone derivatives
Inspired by the previous findings on the structural requirements needed for good antimalarial activity by chalcones against Plasmodium proteases, seventeen chalcone derivatives were designed and synthesized using Claisen-Schmidt condensation of appropriate aldehydes and methyl ketones. The structures of these compounds were established using variou... Continue Reading
effect of lauric acid on erectile and testicular dysfunction in diabetic male wistar rats
Diabetes mellitus is a risk factor for reproductive and sexual dysfunction. Standard medications are not completely satisfactory, hence the consideration of natural products as an alternative therapy. Lauric acid is the most abundant constituent of coconut oil, which is renowned for its therapeutic properties. This study sought to investigate the i... Continue Reading
phytochemical and anti snake venom studies on the methanol aerial part extract of tacazzea apiculata oliv (periplocaceae)
Tacazzea apiculata (Olive) is a woody climber indigenous to Tropical Africa often used in traditional medicine for the treatment of pain, inflammation, skin infections, diabetes, epilepsy and snakebite. This study aimed to isolate and characterize some of the phytochemical constituent(s) present in aerial part extract of T. apiculata and to scienti... Continue Reading
phytochemical, analgesic and anti-inflammatory studies on the methanol root extract of combretum hypopilinum (diels) okafor (combretaceae)
Combretum hypopilinum (Diels) Okafor belongs to the family Combretaceae, and composed of 20 genera with about 500 species. It is a small to medium sized, deciduous shrub or tree growing from 4 - 18 metres in height, with a rounded or flat heavy crown. The plant is used in ethnomedicine for the treatment of pain, snake bites, jaundice, gonorrhoea, g... Continue Reading
effect of co-administration of metformin and cefixime on some biomarkers in diabetic rats
The incidence of infections in Type 2 Diabetes Mellitus (T2DM) continues to be on the increase, necessitating the combined use of antibiotics and hypoglycaemic agents. Metformin, a biguanide is the first drug of choice in the management of T2DM and is most frequently employed with antibiotics when infections exist as co morbid state. This study inv... Continue Reading
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