comparison of the effect of a single oral dose of cimetidine and propantheline on the pharmacokinetic of paracetamol in human
Comparison of the effects of a single oral dose of cimetidine and propantheline on the pharmacokinetics of paracetamol were studied with paracetamol (1g) administered alone, concurrently with cimetidine (400mg), delay (1 hour) with cimetidine (400mg), concurrently with paracetamol (15mg) and delay (1 hour) with propantheline (15mg) respectively. Pa... Continue Reading
pharmacognostic and biological studies of the leaves and stem-bark of hymenocardia acida, tul. (euphorbiaceae)
This study deals with the pharmacognostic and biological aspects of the leaves and stem bark of Hymenocardia acida Tul (Family Euphorbiaceae). Euphorbiceae is a large and heterogeneous family found mainly in the tropics and sub-tropics. H. acida is a savannah shrub or tree with twisted trunk usually less than 4.5 m high but sometimes attaining as m... Continue Reading
phytochemical and anti snake venom studies on the methanol aerial part extract of tacazzea apiculata oliv (periplocaceae)
Tacazzea apiculata (Olive) is a woody climber indigenous to Tropical Africa often used in traditional medicine for the treatment of pain, inflammation, skin infections, diabetes, epilepsy and snakebite. This study aimed to isolate and characterize some of the phytochemical constituent(s) present in aerial part extract of T. apiculata and to scienti... Continue Reading
assessing the oral health records and antibiogram of anaerobic bacteria isolates from patients visiting dental unit
(A CASE STUDY OF AHMADU BELLO UNIVERSITY MEDICAL CENTER, ZARIA)
Oral health can be a good indicator of general health and has been linked to systemic diseases, therefore, maintaining good oral hygiene is important. Oral infections are polymicrobial with dental caries and periodontal disease being the major oral conditions affecting the public. A retrospective study on patients with orodontal conditions in the d... Continue Reading
antidiarrhoeal and toxicity studies on methanol leaf extract of combretum hypopilinum diels (combretaceae) in mice and rats
The plant Combretum hypopilinum has been used in traditional medicine to treat diarrhoea and other gastrointestinal diseases. This study aimed to investigate the antidiarrhoeal activity and toxicity profile of the methanol leaf extract of Combretum hypopilinum (MECH) in mice and rats. The phytochemical screening was conducted and the oral median le... Continue Reading
incidence of multidrug resistant staphylococcus aureus and enterobacteriaceae from groundnut cakes (kuli-kuli) and roasted groundnuts obtained from zaria metropolis
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium responsible for several difficult-to-treat infections in humans. Previous studies reported the identification of MRSA in food demonstrating that food can represent a source of Staphylococcus aureus which may carry the mecA gene. The aim of this study is to determine the incidence of ... Continue Reading
antibiotics susceptibility and molecular characterization of clinical isolates of e. coli
(A CASE STUDY OF AHMADU BELLO UNIVERSITY TEACHING HOSPITAL SHIKA, ZARIA)
Antimicrobial drug resistance is a global challenge with the emergence of resistant bacterial strains worldwide. This study was conducted to determine the incidence of E. coli in ABUTH Shika, Zaria (from March 2011 to February 2012), their antibiotics susceptibility pattern, molecular characterization and possible presence of E. coli serotype O157:... Continue Reading
comparative in-vitro bioequivalence studies of some brands of metronidazole tablet marketed in zaria, kaduna state
Metronidazole is an antibacterial and antiprotozoal drug used in the treatment of amebiasis, giardiasis, trichomoniasis and other microbial diseases. It is an essential drug commonly found in Nigerian market and has so many generics and dosage forms under various trade names by different manufacturers. The purpose of the study was to evaluate and c... Continue Reading
evaluation of the dissolution and other characteristics of cyclodextrin molecular inclusion complexes of artemether
The present study aimed to improve the dissolution rate, solubility and ultimately, bioavailability of poorly soluble artemether, an antimalarial drug, through inclusion complex formation with hydroxypropyl-?-cyclodextrin. The solid complexes of artemether and hydroxypropyl-?-cyclodextrin (HP-?-CD) were prepared at a molar ratio of 1:1, 1:2 and 1:3... Continue Reading
development of a filler-binder disintegrant for direct compression tableting by co-processing microcrystalline cellulose and crospovidone
The aim of the study was to improve the disintegration functionality of microcrystalline cellulose (MCC) as a direct compression excipient in tablet formulation by coprocessing MCCwith crospovidone (CPV), a superdisintegrant. Design of Experiment (DoE) approach was adopted to optimize the composition of the co-processed excipient (CPE). The optimiz... Continue Reading
molecular characterization of multidrug resistant bacterial uropathogens from pregnant women
(A CASE STUDY OF IBADAN METROPOLIS, SOUTH-WEST NIGERIA)
Urinary tract infection (UTI) is one of the commonest infectious diseases of women worldwide, and pregnant women are more predisposed. This study aimed to determine the prevalence of bacterial infecting agents in UTI during pregnancy, to establish their antimicrobial susceptibility profiles, identify the socio-economic factors that promote UTI. Vir... Continue Reading
effect of lauric acid on erectile and testicular dysfunction in diabetic male wistar rats
Diabetes mellitus is a risk factor for reproductive and sexual dysfunction. Standard medications are not completely satisfactory, hence the consideration of natural products as an alternative therapy. Lauric acid is the most abundant constituent of coconut oil, which is renowned for its therapeutic properties. This study sought to investigate the i... Continue Reading
evaluating genomic deoxyribonucleic acid (gdna) of parents and offspring towards determining rickets hereditary link in gonin gora
(A CASE STUDY OF KASO AND JANKASA COMMUNITIES IN KADUNA STATE)
Rickets is still a debilitating disease in various communities of Jankasa, Kaso and Gonin Gora in which about 3-7 percent of the population is affected. Genomic Deoxyribonucleic acid (gDNA) of parents and offspring were evaluated towards determining rickets hereditary link in the population. Four families from Jankasa, Kaso and two families from Go... Continue Reading
phytochemical, analgesic and anti-inflammatory studies on the methanol root extract of combretum hypopilinum (diels) okafor (combretaceae)
Combretum hypopilinum (Diels) Okafor belongs to the family Combretaceae, and composed of 20 genera with about 500 species. It is a small to medium sized, deciduous shrub or tree growing from 4 - 18 metres in height, with a rounded or flat heavy crown. The plant is used in ethnomedicine for the treatment of pain, snake bites, jaundice, gonorrhoea, g... Continue Reading
controlled release formulations of antiretroviral (arv) drugs using polymethacrylate polymers
To improve patient compliance and ensure better success in the management of HIV, spansule technology was employed to formulate controlled release dosage drug. Generic forms of seven of the most commonly used Anti-retro viral (ARV) drugs (didanosine, indinavir, lamivudine, nelfinavir, nevirapine, stavudine and zidovudine) and their clinically appro... Continue Reading
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