pharmacognostic and biological studies of the leaves and stem-bark of hymenocardia acida, tul. (euphorbiaceae)
This study deals with the pharmacognostic and biological aspects of the leaves and stem bark of Hymenocardia acida Tul (Family Euphorbiaceae). Euphorbiceae is a large and heterogeneous family found mainly in the tropics and sub-tropics. H. acida is a savannah shrub or tree with twisted trunk usually less than 4.5 m high but sometimes attaining as m... Continue Reading
comparison of the effects of cimetidine and diazepam on the pharmacokinetics of paracetamol in healthy human volunteers
The influence of Cimetidine (400 mg) and Diazepam (5 mg) on the pharmacokinetics of oral paracetamol (1000 mg) was studied and compared in eight (8) healthy human under two (2) protocols; concomitant and delayed administration of paracetamol. Subjects received one treatment at each of the five sessions with a 2 weeks wash out period in-between. Par... Continue Reading
phytochemical and anti snake venom studies on the methanol aerial part extract of tacazzea apiculata oliv (periplocaceae)
Tacazzea apiculata (Olive) is a woody climber indigenous to Tropical Africa often used in traditional medicine for the treatment of pain, inflammation, skin infections, diabetes, epilepsy and snakebite. This study aimed to isolate and characterize some of the phytochemical constituent(s) present in aerial part extract of T. apiculata and to scienti... Continue Reading
antidiarrhoeal and toxicity studies on methanol leaf extract of combretum hypopilinum diels (combretaceae) in mice and rats
The plant Combretum hypopilinum has been used in traditional medicine to treat diarrhoea and other gastrointestinal diseases. This study aimed to investigate the antidiarrhoeal activity and toxicity profile of the methanol leaf extract of Combretum hypopilinum (MECH) in mice and rats. The phytochemical screening was conducted and the oral median le... Continue Reading
incidence of multidrug resistant staphylococcus aureus and enterobacteriaceae from groundnut cakes (kuli-kuli) and roasted groundnuts obtained from zaria metropolis
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium responsible for several difficult-to-treat infections in humans. Previous studies reported the identification of MRSA in food demonstrating that food can represent a source of Staphylococcus aureus which may carry the mecA gene. The aim of this study is to determine the incidence of ... Continue Reading
effect of lauric acid on erectile and testicular dysfunction in diabetic male wistar rats
Diabetes mellitus is a risk factor for reproductive and sexual dysfunction. Standard medications are not completely satisfactory, hence the consideration of natural products as an alternative therapy. Lauric acid is the most abundant constituent of coconut oil, which is renowned for its therapeutic properties. This study sought to investigate the i... Continue Reading
molecular characterization of multidrug resistant bacterial uropathogens from pregnant women
(A CASE STUDY OF IBADAN METROPOLIS, SOUTH-WEST NIGERIA)
Urinary tract infection (UTI) is one of the commonest infectious diseases of women worldwide, and pregnant women are more predisposed. This study aimed to determine the prevalence of bacterial infecting agents in UTI during pregnancy, to establish their antimicrobial susceptibility profiles, identify the socio-economic factors that promote UTI. Vir... Continue Reading
evaluating genomic deoxyribonucleic acid (gdna) of parents and offspring towards determining rickets hereditary link in gonin gora
(A CASE STUDY OF KASO AND JANKASA COMMUNITIES IN KADUNA STATE)
Rickets is still a debilitating disease in various communities of Jankasa, Kaso and Gonin Gora in which about 3-7 percent of the population is affected. Genomic Deoxyribonucleic acid (gDNA) of parents and offspring were evaluated towards determining rickets hereditary link in the population. Four families from Jankasa, Kaso and two families from Go... Continue Reading
effect of co-administration of metformin and cefixime on some biomarkers in diabetic rats
The incidence of infections in Type 2 Diabetes Mellitus (T2DM) continues to be on the increase, necessitating the combined use of antibiotics and hypoglycaemic agents. Metformin, a biguanide is the first drug of choice in the management of T2DM and is most frequently employed with antibiotics when infections exist as co morbid state. This study inv... Continue Reading
design, synthesis, antimalarial evaluation and computational studies of some chalcone derivatives
Inspired by the previous findings on the structural requirements needed for good antimalarial activity by chalcones against Plasmodium proteases, seventeen chalcone derivatives were designed and synthesized using Claisen-Schmidt condensation of appropriate aldehydes and methyl ketones. The structures of these compounds were established using variou... Continue Reading
antibiotics susceptibility and molecular characterization of clinical isolates of e. coli
(A CASE STUDY OF AHMADU BELLO UNIVERSITY TEACHING HOSPITAL SHIKA, ZARIA)
Antimicrobial drug resistance is a global challenge with the emergence of resistant bacterial strains worldwide. This study was conducted to determine the incidence of E. coli in ABUTH Shika, Zaria (from March 2011 to February 2012), their antibiotics susceptibility pattern, molecular characterization and possible presence of E. coli serotype O157:... Continue Reading
controlled release formulations of antiretroviral (arv) drugs using polymethacrylate polymers
To improve patient compliance and ensure better success in the management of HIV, spansule technology was employed to formulate controlled release dosage drug. Generic forms of seven of the most commonly used Anti-retro viral (ARV) drugs (didanosine, indinavir, lamivudine, nelfinavir, nevirapine, stavudine and zidovudine) and their clinically appro... Continue Reading
phytochemical, analgesic and anti-inflammatory studies on the methanol root extract of combretum hypopilinum (diels) okafor (combretaceae)
Combretum hypopilinum (Diels) Okafor belongs to the family Combretaceae, and composed of 20 genera with about 500 species. It is a small to medium sized, deciduous shrub or tree growing from 4 - 18 metres in height, with a rounded or flat heavy crown. The plant is used in ethnomedicine for the treatment of pain, snake bites, jaundice, gonorrhoea, g... Continue Reading
formulation studies of acacia sieberiana gum in choroquine and metronidazole matrix tablets
The crude plant gum from African Acacia sieberiana was purified and investigated for use as a matrix excipient for chloroquine phosphate and metronidazole tablet formulations. The chromatographic analysis of the acid hydrolysed gum revealed the presence of rhamnose, galactose, ribose, xylose and fructose. The viscosity was found to increase with in... Continue Reading
development of a filler-binder disintegrant for direct compression tableting by co-processing microcrystalline cellulose and crospovidone
The aim of the study was to improve the disintegration functionality of microcrystalline cellulose (MCC) as a direct compression excipient in tablet formulation by coprocessing MCCwith crospovidone (CPV), a superdisintegrant. Design of Experiment (DoE) approach was adopted to optimize the composition of the co-processed excipient (CPE). The optimiz... Continue Reading
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