This study assessed knowledge and prevention of the risk of contraceptives use among women in Kwara State, Nigeria. A proportional sampling procedure was used for the selection of 378 respondents between the ages 20 - 44 in the selected local government areas in Kwara State. Questionnaire was used to collect data for this study. The demographic variables were analyzed using frequency and percentage distributions. The mean and standard deviation were used to answer the research questions. The inferential statistic of Chi-square were used to test hypotheses one and two, whereas hypotheses three, four, five and six, which sought for differences among age groups and marital status on their knowledge and prevention of contraceptive risk were tested using the Analysis of Variance (ANOVA) all at 0.05 level of significance. This gave rise to six (6) major findings. The study found that, knowledge of contraceptive risks among women in Kwara State is significant with high mean score (X) of 3.76 which is greater than the decision mean of 3.00. Also, the preventive measures of contraceptive risks exists due to the knowledge possessed by women who uses contraceptives in Kwara State is highly significant with the mean score (X) of 4.00, which is also greater than the decision mean of 3.00. This led to the conclusion that women in Kwara State are knowledgeable about the risk of contraceptives and as well possessed the knowledge of its preventive measures. To this therefore, the researcher recommends that health talks about the prevention of contraceptives risk should be in continuum during antenatal and postnatal care in respective clinics. Women should also consider their health status and understand the risk involved in each method of contraceptive chosen to avoid further complications.