This research work investigated the relationship between parental communication styles and substance use of adolescents among secondary school students in Kaduna State, Nigeria. The study employed the descriptive survey method involving the use of questionnaire. The total population for the study was all substance use adolescents in Kaduna State. Three hundred and sixty-three (363) respondents were purposively selected from 12 selected secondary schools in the three senatorial zones of the state for the study, as 351 responded and returned the completed questionnaires representing 98.3%. The instruments used in the study were the 18-item parental communication measures adopted from life Skills Training questionnaire designed and standardized by Botvin (2007) and Adolescent Alcohol and Drug Involvement Scale adopted from Mobereg's (2011) Students' Behaviour of Substance Use. Three objectives, three questions and three hypotheses were used and tested using Pearson Product Moment Correlation Coefficient. Results showed that there was a significant positive relationship between aggressive parental communication style and substance use of adolescents with (r = 0.945, p = 0.000). There is also a significant negative relationship between assertive parental communication style and substance use of adolescents among secondary school students with (r = -0.574, p = 0.000). Also, the findings showed a significant positive relationship between passive parental communication style and substance use of adolescents with (r = 0.482, p = 0.001). It was recommended that parents, counselors, psychotherapists and stakeholders in education should be exposed to the adequate counselling on the relationship between parental communication style and substance abuse of adolescents.