This study made used of survey design to examine Drug Abuse on Socio-Emotional Behaviour Among Secondary School Students in Kaduna state. Five objectives, research questions and hypotheses were stated which guided the study. To achieve the objectives, data were collected from 370 (male=227 and female= 143), participants using a questionnaire structured on a four points fixed response format. The collected data were sorted and analyzed to test the five non directional hypotheses using independent sample t- test and chi square at alpha = .05. The result identified curiosity, peer pressure, and inability in maintaining inter-personal communications among others as significant factors influencing drug abuse among students, χ2 (9) = 120.720, p < .05. Drug abuse also significantly influence social, t (198) = 8.45, p < .05, and emotional behaviour, t (198) = 7.64, p < .05, of secondary school students in Kaduna State with more males than females being affected. It also revealed that drug abuse negatively influences students school work, χ2 (3) = 41.21, p < .05 with users reporting poor level of school work compared to others. Gender was also found to significantly influence drug abuse, χ2 (3) = 33.76, p < .05 with more males than females secondary school students in Kaduna State reporting drug abuse behaviour. Based on this, it was recommended that parents should make deliberate effort to instill high moral standard and ensure they monitor the kind of friends their children hang out with in the community, as doing so will help reduce drug abuse behaviour among secondary school students in Kaduna State, Nigeria.