This study investigated the Pedagogical Approaches to Teaching and Learning Entrepreneurship Education in Library and Information Science Schools in the Universities in North-West States of Nigeria. The study adopted a survey research design and questionnaire was used as instrument for data collection. The population of the study was made up of the academic staff and students of LIS Schools in Ahmadu Bello University Zaria and Umaru Musa Yar'adua University, Katsina. Twenty nine, 29 academic staff and 283 students were selected as sample for the study, five research questions and three hypotheses were formulated and tested. Descriptive and Inferential statistics were used to analyse the data collected. All three null hypotheses formulated were rejected suggesting that There is significant relationship between the course content and the pedagogical approaches to teaching and learning of entrepreneurship education in the LIS Schools studied; There is significant relationship between the pedagogical approaches and the effect of entrepreneurship education on the LIS Students studied and there is significant relationship between the challenges of teaching and learning pedagogical approaches and the effects on LIS students. The study established among others, that there is some level of compliance with the National Universities Commission Standard on Entrepreneurship Education in the Library and Information Science Schools studied. But the partial implementation of the NUC content area and the use of traditional teaching methods affect the graduates' entrepreneurial skills upon completion of their programmes. The study concludes that effectiveness of the entrepreneurial pedagogy is of paramount importance and should be developed in the university system. The study recommends for the full implementation of NUC entrepreneurship course contents and issues concerning teaching strategies, funding of the programme, start-up capital and planning, supervision and evaluation should be reviewed.