This study examined the effects of simulation model on students? academic Performance, attitude and retention in qualitative analysis among Senior Secondary School students in Kaduna state. The motive behind the study is connected to persistent failure of students in SSCE due to poor attitude generating low retention among learners. In line with this, four research questions and hypotheses were developed. The study adopted pretest posttest Quasi-experimental control group design. The population of the study comprised of eight (8) governments-owned, coeducational Senior Secondary Schools in Zaria Inspectorate Zone with a total number of 645 SSS II Chemistry students. Two Senior Secondary Schools were systematically selected for the study. In the school selected, intact SS II classes were used from forming a sample size of 102 Students. Two validated instruments, Qualitative Analysis Performance Test (QAPT) and Students Attitude towards Qualitative Analysis Concepts Questionnaire (SAQACQ) were developed by the researcher and used for data collection. The reliability coefficient of the QAPT and SAQAQ were 0.66 and 0.96 respectively. Research questions were answered using mean and standard deviation, while null hypothesis were tested at p ≤0.05 level of significance using t-test and Kruskalwalis test. Statistics and the research findings show that there was significance difference in the academic Performance of male and female student?s taught qualitative analysis concept using simulation. I concluded that the effect of simulation method on students? academic performances and attitude in qualitative analysis concepts as measured by QAPT and SAQAQ where statistically significant towards improving teaching and learning. This study recommended that the Federal and state ministry of education should provide relevant materials in secondary schools for developing and implementing simulation teaching to enhance attitude and performance of students. Similarly, Secondary school teachers should be trained by the teacher training institutions on developing and utilization of simulation methods in teaching