The study examined the effects of guided Inquiry method on academic performance of chemistry students in selected senior secondary schools in Kaduna state. The study used a quasi-experimental research design.A sample of 120 senior secondary 11 (SS2) chemistry students were selected by random sampling from 2 urban and 2 rural schools which comprised both boys and girls with 30 students each in experimental and control groups respectively. The research instruments comprised of chemistry Achievement Test (CAT). The CAT contained 30 multiple choice questions with four options (A-D) and 5 essay questions. The students were divided into two groups; Experimental and control groups which were subjected to inquiry method and traditional methods of teaching respectively. The t-test statistics was used to analyze the data. Major findings revealed that Chemistry students taught using inquiry teaching method performed significantly better than their counterparts taught using traditional teaching method. Hence the study concluded that the inquiry teaching method produced students with significantly higher academic performance inChemistry. The study therefore recommend among others that the use of Inquiry teaching method should be encouraged in all Secondary Schools that offer Chemistry to its students in Kaduna State and other states in Nigeria, also Government should sponsor teachers to attend various workshops and seminars on appropriate and effective use of the inquiry teaching method.