This research work was carried out to assess the impact of resist techniques of fabric decoration on students' interest in clothing and textiles in Borno State, Nigeria. The study had four specific objectives, four research questions and four null hypotheses which were formulated and tested at 0.05 level of significance. The research design adopted for the study was quasi experimental. The population for the study was all JSS3 students that offer home economics in one hundred and eighty (180) secondary schools in both public and private. A purposive sampling technique was used to select two secondary schools, one from public, government secondary school Uba Borno and one from private, AbdulkadirBenishiek Staff School, Maiduguri. One intact class was used in each of the schools and a sample size of one hundred and eighty-eight (188) students was used for the study. The instrument used for data collection was a self-designed questionnaire. Mean and standard deviation were used to answer the stated research questions. Two sample t-test was used to test all the null hypotheses. From the result of the study, hypotheses one, two and four were rejected, while hypothesis three was retained. The major findings from the data analysis and test of the hypotheses revealed that students who were exposed to resist techniques of fabric decoration had their interest in clothing and textiles significantly motivated when compared to their counterparts who were not exposed. Based on the findings of this study, it was recommended among others that prospective students should be exposed to resist technique of fabric decoration as early as possible in the course of teaching and learning of the subject so as to motivate and sustain their interest. There is a need for career awareness and counseling at the onset of the junior secondary school such that students get acquainted with the different career opportunities before making their choice of subjects in their final examinations.