This study is a comparative analysis of academic performance of part-time and regular students of business education in federal colleges of education in North-west Nigeria. Five research questions were answered and five null hypotheses were tested. The study used ex-post facto research design and the total population used was 886 NCE III regular and NCE IV part-time business education students in Five Federal Colleges of Education in the North-west Zone, Nigeria from 2015 to 2016 academic sessions. The instrument used for data collection was record of students‟ Cumulative Grade Point Average (CGPA) and their files to get records of students‟ age and gender and class list from office of the Head of Department to get class size for the 2015/2016 academic sessions. The research questions were answered using mean difference and standard deviation while t-test was used to test all the stated null hypotheses. The analysis revealed that the regular students perform better than the part-time students with a merit for the regular and a pass for the part-time students. Findings also revealed that individual differences in terms of age, gender and the class size of the part-time and regular students are linked to differences in the academic achievements of students. The study concluded that the younger and the older age students in the regular program perform better than the younger and older students in the part-time business education program in the federal colleges of education in North-west Nigeria. It further concluded that the fewer the class-size the better the performance. The researcher made some recommendations among which include that lecturers in the colleges of education especially those teaching the part - time students to use appropriate teaching methods that will favour the old-age students in part-time program to help them cope with learning situations. The study further recommended that the class size of part-time programme should be decongested to the recommended student-teacher ratio of atleast 1 - 50 for effective teaching and learning.