This study investigated the impact entrepreneurial skills acquisition on Home Economics students' performance in junior secondary schools in Kaduna State, Nigeria. The study set out to: find out the impact of entrepreneurial skills acquisition on the performance of home economics students in junior secondary schools in Kaduna state; ascertain the impact of entrepreneurial skills acquisition on the performance of urban and rural students of home economics in junior secondary schools in Kaduna state; and examine the impact of entrepreneurial skills acquisition on the performance of male and female home economics students in junior secondary schools in Kaduna state.Three (3) corresponding research questions and three (3) hypotheses were formulated for the study. The research used quasi - experimental design, the single group method. The population of the study consisted 14,830 students studying home economics in junior secondary schools in Kaduna and Rigachikun Education zones. The instrument tagged "Home Economics Entrepreneurial Skills Performance Test (HEESPAT)" was used to obtain data for the study, which was pilot-tested and a reliability coefficient of 0.83 was obtained. Data collected were analyzed using descriptive statistics to answer the research questions while inferential statistics ANCOVA was used to test hypothesis one. Independent sample t-test was used to test hypotheses two and three. Findings from the study revealed that entrepreneurial skills acquisition had positive impact on the performance of home economics students in junior secondary schools in Kaduna state; skills acquisition had impact on the performance of urban and rural home economics students in junior secondary schools of Kaduna state. It was recommended among others that: there should be school based enterprises where both rural and urban home economics students identify potential business plans, create and operate small businesses using the school as mini-incubators.