This study was on development and acceptability of natural, synthetic and mixed leatherworks for interior decoration in Kano State, Nigeria. Seven specific objectives and six research questions were formulated to guide the study. R&D design was adopted for the study. The population of the study was552 respondents and 20 panel of judges who were academic staff of Saadatu Rimi College of Education, Kumbotso, Kano. The sample for the study was 217 and 20 panel of judges. Four rating questionnaire and hedonic scale were used as instrumentsfor data collection. The data collected were coded and analyzed to answer research questions using descriptive statistics of frequency and percentages as well as mean and standard deviation. The result revealed that leather carpet, pouf and wall hangers are mostly used among the available items for interior decoration. Other decorative items also used include leather sofas, throw pillow, mat, wall cover, hand fan and foot mat in Kano State. The findings revealed that natural and mixed (natural and synthetic) leatherworks have smooth texture while synthetic leatherwork has coarse texture. The texture of natural and mixed (natural and synthetic) leatherworks ere accepted by the consumers. The results also revealed that the natural leatherwork is lighter than synthetic and mixed (natural and synthetic) leatherworks is heavy. The weight of natural leatherworks was accepted by the consumers and that of synthetic and mixed (natural and synthetic) was not accepted. The findings also showed that the odourof synthetic leatherwork is good while that of natural and mixed (natural and synthetic) leatherworks is foul. The result also found that natural leatherworks are costlythan synthetic and mixed (natural and synthetic) hence, mixed leatherworks was more accepted. The study concluded among others that natural and mixed (natural and synthetic) leatherworks have smooth texture than the synthetic leatherwork and this made the consumers to accept natural and mixed leatherworks over synthetic. It was recommended among others thatindividuals, Home Economists and industries involved in the production of leatherworks should put efforts in producing leatherworks with soft texture since the leather users prefer leatherworks with smooth and soft texture.Home Economists and leatherworks enterprise should produce leatherworks that are not so heavy and weighty since the leather users prefer leatherworks that are very light and not opaque.