This study investigated the Effect ofGraphic-Advance-Organizers on Interest and Performance among Upper Basic Science Secondary School Students in Potiskum Education zone, Yobe State, Nigeria.The study was quasi experimental control group involving pretest and posttest that utilized the non-randomized designusing intact classes.The study was conducted involving population of Eight Thousand and Five (8,057) students, sample size of Two Hundred and Seventy-Six (276) students experimental (n=153) and control (n=123).A sample of four schools from the population were randomly selected which were pretested and subjected to ANOVA.Two out the four schools that have similar mean scores were selected for the study.Simple random sampling by balloting was used to assign the two schools selected to experimental and control groups. The instruments used for data collection are Basic Science Performance Test (BSPT) and Basic Science Students‟ Interest Questionnaire (BSSIQ). Descriptive statistics was used to analyze responses to the four (4) stated research questions and Hypothesis 1 was analyzed using Wilcoxon Signed Rank Test, hypothesis 2 and 4 were computed by ANCOVA while hypothesis 3 was analyzed by Kruskal Wallis.The analyses and results of the data collected were analyzed using the Statistical Package for Social Science (SPSS) and the level of significance adopted for rejecting or retaining the stated hypotheses was set at P≤0.05.The findings from the study indicates that: there was a significant difference between the mean interest level of students in the experimental group before and after the treatment. There was a significant difference in the mean posttest scores of the experimental and control groups. There was a significant difference between the mean interest level of male and female students in the experimental group before and after the treatment. There was no significant difference in the mean posttest scores of male and female of the students taught using Graphic-Advance-Organizers. It was concluded that Graphic- Advance-Organizers has the potential of enhancing Junior Secondary School Students‟ Interest and Performance in Basic Science. Based on the findings of the research it was recommended among others that there should be training and retraining by SUBEB, STAN etc. of Basic Science teachers on the use and design of Graphic-Advance-Organizers, secondly Graphic-Advance-organizers should be used by Basic Science teachers in teaching at Junior Secondary schools, also the use of Graphic-Advance-organizers should be encouraged in co-educational schools since it is gender friendly.