TABLE OF CONTENTS
TITLE PAGE--------- i
CERIFICATION--------- ii
DEDICATION-------------iii
ACKNOWLEDGEMENT--------------iv
TABLE OF CONTENT--------------v
ABSTRACT ----------------x
CHAPTER ONE
1.0 Introduction
1.1 Background of the study------ 1
1.2 Statement of the problem------ 5
1.3 Aims/Objectives of the study------- 6
1.4 Specific Objectives ------- 6
1.5 Significance of the study---- -- 6
1.6 Scope of the Study------- 7
1.7 Research Questions-------------7
CHAPTER TWO
2.0 Literature Review
2.1 General Classification of Mucuna pruriens--- 9
2.1.1 General Description of Agbala (Mucuna pruriens)- 10
2.1.2 Nutritional properties ------ 11
2.1.3 Phytochemical properties------ 15
2.1.4 Current uses of Mucuna pruriens---- 17
2.1.5 Nutraceutical versatility------ 17
2.1.6 Antioxidant property------ 18
2.1.7 Antivenin property------- 19
2.1.8 Fertility enhancing property----- 20
2.1.9 Growth promoting property----- 21
2.1.10 Hypoglycemic property------ 21
2.1.11Anthelmintic property------ 22
2.2 Review on prevalence of malaria in Nigeria--- 23
2.3 Species of plasmodium------ 29
2.4 Review of kidney markers------ 29
2.5 Markers of Kidney function------ 36
CHAPTER THREE
3.0 MATERIALS AND METHODS
3.1 Materials-------------------37
3.1.1 Samples used -------- 37
3.1.2 Equipments/Apparatuses----- 37
3.1.3 Reagents used-------- 37
3.2 Methods-------------------38
3.2.1 Preparation of plant materials for extraction-- 38
3.2.2 Determination of LD50------ 38
3.2.3 Estimation of antimicrobial activity of Mucuna pruriens 39
3.2.4 Staining Technique------- 40
3.2.5 Urea Estimation------- 41
3.2.6 Estimation of Creatinine------ 42
3.2.7 Bilirubin Estimation------- 43
CHAPTER FOUR
4.0 RESULTS----------------44
4.1 Acute toxicity ---------------44
4.2 Antimalaria Activity------------45
4.3 Creatinine---------------46
4.4 Bilirubin-----------------48
4.5 Urea-----------------50
CHAPTER FIVE
5.0 DISCUSSION, CONCLUSION AND RECOMMENDATION
5.1 Discussion-----------------52
5.2 Conclusion----------------56
5.3 Recommendation--------------57
REFERENCES----------------58
APPENDICES--------------66
